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Article

Kinetic gating of the proton pump in cytochrome c oxidase.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2009

Kim Young C, Wikström Mårten, Hummer Gerhard

Abstract excerpt

Cytochrome c oxidase (CcO), the terminal enzyme of the respiratory chain, reduces oxygen to water and uses the released energy to pump protons across a membrane. Here, we use kinetic master equations to explore the energetic and kinetic control of proton pumping in CcO. We construct models consistent with thermodynamic principles, the structure of CcO, experimentally known proton affinities, and equilibrium...

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Identifiers

PMID: 19666617
DOI: 10.1073/pnas.0903938106
PMCID: PMC2728958

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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