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Article

Roles of Subunit ND2/NuoN in the Proton Pumping Coupling Mechanism of Complex I.

International journal of molecular sciences - 25 Mar 2026

Wadley Andrew E, Narayanan Madhavan, Nakamaru-Ogiso Eiko

Abstract excerpt

Complex I (NADH:quinone oxidoreductase, CI) is central to cellular aerobic energy metabolism. The L-shaped structure of CI is unique, where the hydrophilic arm is responsible for the electron transfer function and the membrane arm operates proton pumping. These two functional sites are spatially far apart yet functionally connected. This basic core subunit architecture is highly conserved from bacterial to...

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PMID: 41977177
DOI: 10.3390/ijms27072990
PMCID: PMC13073174

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Roles of Subunit ND2/NuoN in the Proton Pumping Coupling Mechanism of Complex I.PMID 41977177Read ↗

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