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Article

A carboxylate switch point controls long-range energy transduction in respiratory Complex I.

Nature communications - 1 Jul 2026

Beghiah Adel, Saura Patricia, Kovalova Terezia, Hoeser Franziska, Friedrich Thorsten, Kaila Ville R I

Abstract excerpt

Complex I is a highly intricate membrane-bound protein complex that powers the cellular energy metabolism by a long-range ( > 300 Å) proton-coupled electron transfer (PCET) reaction. Here, we investigate the highly debated coupling mechanism of Complex I by probing the charge transfer reaction along its functionally central carboxylate pathway (E-channel). By combining biophysical and site-directed mutagenesis...

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Share to Carboxylic Acids
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42386739
DOI: 10.1038/s41467-026-74767-6
PMCID: PMC13324432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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