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Article

Operant behavior is reliably impaired in a mouse model of Angelman syndrome

2026-03-20

Abstract excerpt

<title>Abstract</title> <p> Angelman syndrome (AS) is a neurodevelopmental disorder characterized by cognitive impairment, absent speech, seizures, motor and sleep impairments, and caused by loss of function of the maternal copy of the <italic>UBE3A</italic> gene. Modeling the AS phenotype in preclinical models across behavioral domains is critical for testing of new therapeutics. Our previous work reported be...

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Literature Corpus work
e4974dc6-8aae-5b1d-b22a-9c1c655fc729
DOI
10.21203/rs.3.rs-9043922/v1
Open publication

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Operant behavior is reliably impaired in a mouse model of Angelman syndromeDOI 10.21203/rs.3.rs-9043922/v1
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