Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Behavioral deficits in an Angelman syndrome model: effects of genetic background and age.

Behavioural brain research - 15 Apr 2013

Huang Hsien-Sung, Burns Andrew J, Nonneman Randal J, Baker Lorinda K, Riddick Natallia V, Nikolova Viktoriya D, Riday Thorfinn T, Yashiro Koji, Philpot Benjamin D, Moy Sheryl S

Abstract excerpt

Angelman syndrome (AS) is a severe neurodevelopmental disorder associated with disruption of maternally inherited UBE3A (ubiquitin protein ligase E3A) expression. At the present time, there is no effective treatment for AS. Mouse lines with loss of maternal Ube3a (Ube3a(m-/p+)) recapitulate multiple aspects of the clinical AS profile, including impaired motor coordination, learning deficits, and seizures. Thus,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angelman Syndrome
Share to Behavior, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, 129 Strain

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Neuropsychological Tests

Share to Single-Blind Method

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 23295389
DOI: 10.1016/j.bbr.2012.12.052
PMCID: PMC3629944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Behavioral deficits in an Angelman syndrome model: effects of genetic background and age.PMID 23295389Read ↗

Behavioral Evaluation of Angelman Syndrome Mice at Older Ages.Semantic proximity Read ↗

Operant behavior is reliably impaired in a mouse model of Angelman syndromeSemantic proximity Read ↗

Angelman Syndrome: From Mouse Models to Therapy.Semantic proximity Read ↗

Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice.Semantic proximity Read ↗

Angelman Syndrome.Semantic proximity Read ↗

Insulin-like growth factor-2 does not improve behavioral deficits in mouse and rat models of Angelman SyndromeSemantic proximity Read ↗

Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome.Semantic proximity Read ↗

Enhanced Operant Extinction and Prefrontal Excitability in a Mouse Model of Angelman Syndrome.Semantic proximity Read ↗

Of mothers and myelin: Aberrant myelination phenotypes in mouse model of Angelman syndrome are dependent on maternal and dietary influences.Semantic proximity Read ↗

Neurobehavioral and electroencephalographic abnormalities in Ube3a maternal-deficient mice.Semantic proximity Read ↗

Angelman syndrome: a journey through the brainSemantic proximity Read ↗

Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.