Article
Enhanced Operant Extinction and Prefrontal Excitability in a Mouse Model of Angelman Syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Mar 2018
Sidorov Michael S, Judson Matthew C, Kim Hyojin, Rougie Marie, Ferrer Alejandra I, Nikolova Viktoriya D, Riddick Natallia V, Moy Sheryl S, Philpot Benjamin D
Abstract excerpt
Angelman syndrome (AS), a neurodevelopmental disorder associated with intellectual disability, is caused by loss of maternal allele expression of UBE3A in neurons. Mouse models of AS faithfully recapitulate disease phenotypes across multiple domains, including behavior. Yet in AS, there has been only limited study of behaviors encoded by the prefrontal cortex, a region broadly involved in executive function and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.