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Article

Multidimensional analysis of behavior predicts genotype with high accuracy in a mouse model of Angelman syndrome.

Translational psychiatry - 3 Oct 2022

Tanas Joseph K, Kerr Devante D, Wang Li, Rai Anika, Wallaard Ilse, Elgersma Ype, Sidorov Michael S

Abstract excerpt

Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of expression of the maternal copy of the UBE3A gene. Individuals with AS have a multifaceted behavioral phenotype consisting of deficits in motor function, epilepsy, cognitive impairment, sleep abnormalities, as well as other comorbidities. Effectively modeling this behavioral profile and measuring behavioral improvement will be crucial for...

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PMID: 36192373
DOI: 10.1038/s41398-022-02206-3
PMCID: PMC9529912

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