Article
A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel Ube3a mutants.
Molecular autism - 1 Jan 2018
Sonzogni Monica, Wallaard Ilse, Santos Sara Silva, Kingma Jenina, du Mee Dorine, van Woerden Geeske M, Elgersma Ype
Abstract excerpt
Background: Angelman syndrome (AS) is a neurodevelopmental disorder caused by mutations affecting UBE3A function. AS is characterized by intellectual disability, impaired motor coordination, epilepsy, and behavioral abnormalities including autism spectrum disorder features. The development of treatments for AS heavily relies on the ability to test the efficacy of drugs in mouse models that show reliable, and...
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