Courtship and distress ultrasonic vocalizations are disrupted in a mouse model of Angelman syndrome

Abstract excerpt

<title>Abstract</title> <p>Background Angelman syndrome (AS) is a single-gene neurodevelopmental disorder caused by loss of function of the maternal copy of the <italic>UBE3A</italic> gene. Nearly all individuals with AS lack speech, resulting in major impacts on daily life for patients and caregivers. To evaluate new therapies for AS, it is crucial to have a mouse model that characterizes meaningful clinical fe...

Topics

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• Acoustic Stimulation
• Action Potentials
• Angelman Syndrome
• Disease Models, Animal
• Mice
• Phenotype
• Ubiquitin-Protein Ligases
• Vocalization, Animal

Identifiers and source

Literature Corpus work

46e79149-16a3-561a-a958-a975d6e378af

DOI

10.21203/rs.3.rs-5953744/v1