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Article

Structural analysis of the effects of mutations in Ubl domain of Parkin leading to Parkinson's disease.

Gene - 5 Feb 2020

Biswas Sima, Roy Riya, Biswas Ria, Bagchi Angshuman

Abstract excerpt

Parkinson's disease (PD) is characterized by progressive death of dopamine producing neurons in the substantia nigra pars compacta of the mid brain. Dysfunction of an E3 ligase protein, Parkin, encoded by PARK2 gene, results in accumulation of misfolded proteins in brain cells which lead to the onset of PD. Parkin is a multi-domain protein consisting of N-terminal ubiquitin-like domain (Ubl) followed by RING0,...

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Source

Identifiers

PMID: 31647998
DOI: 10.1016/j.gene.2019.144186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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