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Comprehensive review on how platinum- and taxane-based chemotherapy of ovarian cancer affects biology of normal cells

31 Oct 2018

Abstract excerpt

One of the most neglected aspects of chemotherapy are changes, and possible consequences of these changes, that occur in normal somatic cells. In this review, we summarize effects of selected drugs used to treat ovarian cancer (platin derivatives-cisplatin and carboplatin; and taxanes-paclitaxel and docetaxel) on cellular metabolism, acquisition of reactive stroma features, cellular senescence, inflammatory...

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PMID: 30382284
DOI: 10.1007/s00018-018-2954-1

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