Article

A novel ALDH1A1 inhibitor blocks platinum-induced senescence and stemness in ovarian cancer

2022-05-10

Abstract excerpt

Ovarian cancer is a deadly disease attributed to late-stage detection as well as recurrence and development of chemoresistance. Ovarian cancer stem cells (OCSCs) are hypothesized to be largely responsible for emergence of chemoresistant tumors. Although chemotherapy may initially succeed at decreasing the size and number of tumors, it leaves behind residual malignant OCSCs. In this study, we demonstrate that Aldeh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f5f9c54-d4a3-5fac-b7af-24de75277c3c
DOI: 10.1101/2022.05.09.491218

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A novel ALDH1A1 inhibitor blocks platinum-induced senescence and stemness in ovarian cancerDOI 10.1101/2022.05.09.491218Read

A novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian CancerSemantic proximity Read

Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian CancerSemantic proximity Read

ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling.Semantic proximity Read

Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic MalignanciesSemantic proximity Read

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer ChemotherapySemantic proximity Read

Platinum-Induced Mitochondrial OXPHOS Contributes to Cancer Stem Cell Enrichment in Ovarian CancerSemantic proximity Read

MicroRNAs overexpressed in ovarian ALDH1-positive cells are associated with chemoresistanceSemantic proximity Read

The Concept of Cancer Stem Cells: Elaborating on ALDH1B1 as an Emerging Marker of Cancer ProgressionSemantic proximity Read

Autophagy-mediated ID1 turnover dictates chemo-resistant fate in ovarian cancer stem cellsSemantic proximity Read

Single-cell analysis of a high-grade serous ovarian cancer cell line reveals transcriptomic changes and cell subpopulations sensitive to epigenetic combination treatmentSemantic proximity Read

Characterization of stem cell and cancer stem cell populations in ovary and ovarian tumorsSemantic proximity Read

Ovarian cancer stem cell-specific gene expression profiling and targeted drug prescreeningSemantic proximity Read