Article

Mechanisms of AAV neutralization by human alpha-defensins

2024-09-25

Abstract excerpt

Antiviral immunity compromises the efficacy of adeno-associated virus (AAV) vectors used for gene therapy. This is well understood for the adaptive immune response. However, innate immune effectors like alpha-defensin antimicrobial peptides also block AAV infection, although their mechanisms of action are unknown. To address this gap in knowledge, we investigated AAV2 and AAV6 neutralization by human neutrophil pe...

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Literature Corpus work: e48951bf-98f9-53aa-a96e-7cc4859eb491
DOI: 10.1101/2024.09.25.614754

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