Alpha-defensin binding expands human adenovirus tropism

Abstract excerpt

Mammalian α-defensins are a family of abundant effector peptides of the mucosal innate immune system. Although primarily considered to be antimicrobial, α-defensins can increase rather than block infection by certain prominent bacterial and viral pathogens in cell culture and in vivo . We have shown previously that exposure of mouse and human adenoviruses (HAdVs) to α-defensins is able to overcome competitive inh...

Topics

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• A549 Cells
• Adenoviridae
• Adenoviridae Infections
• CAR-T cell therapy research
• Viral gastroenteritis research and epidemiology
• Viral Infections and Immunology Research
• Viral Infectious Diseases and Gene Expression in Insects
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

7249e4d1-2061-5599-90a7-a6b1ec7bba46

DOI

10.1101/2024.05.30.596681