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Evading and overcoming AAV neutralization in gene therapy

9 Dec 2022

Abstract excerpt

Adeno-associated virus (AAV)-derived viral vectors are a promising platform for the delivery of curative, life-changing therapies to a huge number of patients with monogenic disorders. There are currently over 250 clinical trials ongoing worldwide. However, for these therapies to benefit as many patients as possible, techniques must be developed to treat those with pre-existing immunity and to potentially allow...

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PMID: 36503641
DOI: 10.1016/j.tibtech.2022.11.006

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