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AAV-based gene delivery of antimicrobial peptides to combat drug-resistant pathogens

6 Jan 2025

Abstract excerpt

Antimicrobial peptides (AMPs) have emerged as potential alternatives to conventional antibiotics due to their novelty and multiple mechanisms of action. Because they are peptides, AMPs are amenable to bioengineering and suitable for cloning and expression at large production scales. However, the efficient delivery of AMPs is an unaddressed issue, particularly due to their large size, possible toxicities, and the...

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PMID: 39760495
DOI: 10.1128/aem.01702-24

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