Article

Multi-Channel smFRET study reveals a Compact conformation of EF-G on the Ribosome

2024-01-28

Abstract excerpt

<h4>ABSTRACT</h4> While elongation factor G (EF-G) is crucial for ribosome translocation, the role of its GTP hydrolysis remains ambiguous. EF-G’s indispensability is further exemplified by the phosphorylation of human eukaryotic elongation factor 2 (eEF2) at Thr56, which inhibits protein synthesis globally, but its exact mechanism is not clear. In this study, we developed a multi-channel single-molecule FRET (sm...

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Literature Corpus work: 4287cd69-46da-50c9-8ebf-006a43857f26
DOI: 10.1101/2024.01.27.577133

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