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A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance

19 Jan 2016

Abstract excerpt

Antibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from the inhibitory effects of an antibiotic. We present here the first detailed structural characterization of such a target protection mechanism mediated through a protein-protein interaction, revealing the architecture of the complex formed between the FusB...

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PMID: 26781961
DOI: 10.1038/srep19524

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