Article

NASH patient liver derived organoids exhibit patient specific NASH phenotypes and drug responses

2019-10-03

Abstract excerpt

To determine if patient liver derived organoids can in principle be a useful experimental model for non alcoholic staetohepatitis (NASH), we derived to our knowledge for the first time bipotent ductal organoids from endstage NASH patient livers, and for comparison from normal donor livers. We found that all tested NASH liver derived organoids exhibited a profound failure to dedifferentiate from the hepatic state b...

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Literature Corpus work: d8c0f18e-7db7-5f00-9fa5-32a8c3856c2e
DOI: 10.1101/791467

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