Article

A p53 peptide mucosal vaccine induces cellular and humoral immunity and anti-tumor effects in a murine colorectal cancer model

2025-10-23

Abstract excerpt

<title>Abstract</title> <p> Many patients with metastatic and recurrent colorectal cancer (CRC) have poor outcomes, due in part to resistance to current treatment approaches including immune checkpoint inhibitors, which have activity in only a subset of patients. Missense mutations in the <italic>TP53</italic> gene are found in about 65% of CRCs, but no current treatment approach targets mutant <italic>TP53</...

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Literature Corpus work: e45f1b30-44ba-5c2f-80e1-1ff83eebd6ca
DOI: 10.21203/rs.3.rs-7652612/v1

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