Article

A Peptide-Based, LNP-Free mRNA Vaccine Targeting Carcinoembryonic Antigen (CEA) for Potent Colorectal Cancer Immunotherapy: Development, Structural Dynamics, and Preclinical Efficacy

2026-04-28

Abstract excerpt

<h4>Background: </h4> Colorectal cancer (CRC) continues to be a leading cause of global oncology-related deaths. While mRNA vaccines delivered via lipid nanoparticles (LNPs) have achieved clinical success, challenges regarding systemic inflammatory potential, complex multi-step manufacturing, and cold-chain dependence persist. This study explores an alternative delivery paradigm using Nona-arginine (R9), a cell-pe...

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Literature Corpus work: e3a5b315-91fc-58d2-83cb-d8c5c3127715
DOI: 10.20944/preprints202604.1961.v1

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