Bioinformatics, Molecular Docking analysis and Cell Culture Testing of Mutated p53 and Overexpressed CEA in Lung Cancer for mRNA Vaccine Development

Abstract excerpt

<h4>Background: </h4> Lung cancer, particularly non-small cell lung cancer (NSCLC), remains the leading cause of cancer-related deaths globally. Mutations in TP53 and overexpression of carcinoembryonic antigen (CEA) are common in NSCLC, providing attractive targets for immunotherapy. Recent advances in messenger RNA (mRNA) vaccine technology offered new opportunities to elicit targeted immune responses against tum...

Topics

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• CAR-T cell therapy research
• Immunotherapy and Immune Responses
• Monoclonal and Polyclonal Antibodies Research
• RNA and protein synthesis mechanisms
• RNA Interference and Gene Delivery
• SARS-CoV-2 and COVID-19 Research
• vaccines and immunoinformatics approaches
• Viral Infections and Immunology Research

Identifiers and source

Literature Corpus work

f0d37596-e626-5dbd-be8a-4efe9729e147

DOI

10.20944/preprints202506.1569.v1