Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormal H3K4 enzyme catalytic activity and neuronal morphology caused by ASH1L mutations in individuals with Tourette syndrome.

European child & adolescent psychiatry - 1 Nov 2024

Zhang Cheng, Liu Wenmiao, Xu Lulu, Liu Shiguo, Che Fengyuan

Abstract excerpt

ASH1L potentially contributes to Tourette syndrome (TS) and other neuropsychiatric disorders, as our previous studies have shown. It regulates essential developmental genes by counteracting polycomb-mediated transcriptional repression, which restricts chromatin accessibility at target genes. ASH1L is highly expressed in the adult brain, playing a crucial role in the early stage. However, it remains unclear how...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Histone-Lysine N-Methyltransferase

Share to Neurons

Share to Phenotype

Share to Tourette Syndrome

Source

Identifiers

PMID: 38634863
DOI: 10.1007/s00787-024-02437-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal H3K4 enzyme catalytic activity and neuronal morphology caused by ASH1L mutations in individuals with Tourette syndrome.PMID 38634863Read ↗

Mutations in ASH1L confer susceptibility to Tourette syndrome.Semantic proximity Read ↗

ASH1L may contribute to the risk of Tourette syndrome: Combination of family-based analysis and case-control study.Semantic proximity Read ↗

Dynamic Regulation OF The Chromatin Environment By Ash1L Modulates Human Neuronal Structure And FunctionSemantic proximity Read ↗

De novo variants in SIAH1, encoding an E3 ubiquitin ligase, are associated with developmental delay, hypotonia and dysmorphic features.Semantic proximity Read ↗

Expansion of the Genotypic and Phenotypic Spectrum of ASH1L-Related Syndromic Neurodevelopmental Disorder.Semantic proximity Read ↗

Expanding the SIAH1-Associated Phenotypic Spectrum: Insights From Loss-of-Function Variants.Semantic proximity Read ↗

Novel MCA/ID syndrome with ASH1L mutation.Semantic proximity Read ↗

Genetics of Tourette syndrome and tic disorders.Semantic proximity Read ↗

Genome-wide Association Study identifies two novel loci for Gilles de la Tourette SyndromeSemantic proximity Read ↗

Genetics of Tourette Syndrome.Semantic proximity Read ↗

Two novel mutations in SASH1 identified in a familial and a sporadic generalized lentiginosis phenotype in Koreans.Semantic proximity Read ↗

Defects of mutant DNMT1 are linked to a spectrum of neurological disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.