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Article

Parkinson disease related ATP13A2 evolved early in animal evolution

5 Mar 2018

Abstract excerpt

Several human P5-type transport ATPases are implicated in neurological disorders, but little is known about their physiological function and properties. Here, we investigated the relationship between the five mammalian P5 isoforms ATP13A1-5 in a comparative study. We demonstrated that ATP13A1-4 isoforms undergo autophosphorylation, which is a hallmark P-type ATPase property that is required for substrate...

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PMID: 29505581
DOI: 10.1371/journal.pone.0193228

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