Article
Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene.
Cell - 14 May 2004
Li Jin Billy, Gerdes Jantje M, Haycraft Courtney J, Fan Yanli, Teslovich Tanya M, May-Simera Helen, Li Haitao, Blacque Oliver E, Li Linya, Leitch Carmen C, Lewis Richard Allan, Green Jane S, Parfrey Patrick S, Leroux Michel R, Davidson William S, Beales Philip L, Guay-Woodford Lisa M, Yoder Bradley K, Stormo Gary D, Katsanis Nicholas, Dutcher Susan K
Abstract excerpt
Cilia and flagella are microtubule-based structures nucleated by modified centrioles termed basal bodies. These biochemically complex organelles have more than 250 and 150 polypeptides, respectively. To identify the proteins involved in ciliary and basal body biogenesis and function, we undertook a comparative genomics approach that subtracted the nonflagellated proteome of Arabidopsis from the shared proteome of...
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