Cyclic di-AMP alleviates periodontitis by activating PI3K/Akt/NrF2 pathways

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Emerging research demonstrates the regulatory effects of c-di-AMP, a bacterial-derived small molecule secondary messenger, on host immune responses and promoting resistance against infection-related diseases. This study aims to elucidate the role of c-di-AMP in the occurrence and development of periodontitis. <bold>Methods:</bold> We established ligation-induced...

Topics

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• Bone Metabolism and Diseases
• Cytokine Signaling Pathways and Interactions
• Inflammasome and immune disorders
• interferon and immune responses
• NF-κB Signaling Pathways
• Oral microbiology and periodontitis research
• Phosphodiesterase function and regulation
• Viral Infections and Vectors

Identifiers and source

Literature Corpus work

e4148834-87d2-523a-b523-a523d6628fe7

DOI

10.21203/rs.3.rs-4474601/v1