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Punicalagin with anti-inflammatory activities affects Brd-4 mediated chromatin remodeling for attenuating inflammatory osteolysis

2025-12-11

Abstract excerpt

<title>Abstract</title> <p>Inflammatory osteolysis is primarily characterized by an extensive macrophage-mediated inflammatory response coupled with osteoclast (OC) formation, triggered by bacterial byproducts and/or environmental stressors. Punicalagin (PUN), a hydrolyzable tannin derived from pomegranate extract, the suppression of pro-inflammatory cytokine production in macrophages. The therapeutic potential o...

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Literature Corpus work
dbc077e0-3b42-5f79-900b-35cf44a5c884
DOI
10.21203/rs.3.rs-7528092/v1
Open publication

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Punicalagin with anti-inflammatory activities affects Brd-4 mediated chromatin remodeling for attenuating inflammatory osteolysisDOI 10.21203/rs.3.rs-7528092/v1
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