Article

Single-Cell Transcriptomics Identifies Dysregulated Metabolic Programs of Aging Alveolar Progenitor Cells in Lung Fibrosis

2020-07-30

Abstract excerpt

<h4>ABSTRACT</h4> Aging is a critical risk factor in progressive lung fibrotic diseases such as idiopathic pulmonary fibrosis (IPF). Loss of integrity of type 2 alveolar epithelial cells (AEC2s) is the main causal event in the pathogenesis of IPF. To systematically examine the genomic program changes of AEC2s with aging and lung injury, we performed unbiased single cell RNA-seq analyses of lung epithelial cells f...

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Literature Corpus work: a8a18d83-d068-5512-8b2b-e94f5dddb9ea
DOI: 10.1101/2020.07.30.227892

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