Article

N <sup>1</sup> -methylpseudouridine-incorporated mRNA enhances exogenous protein expression and suppresses immunogenicity in primary human fibroblast-like synoviocytes

2022-03-23

Abstract excerpt

Studies conducted using murine arthritis models have indicated that the use of in vitro -transcribed messenger RNA (IVT mRNA) is an effective therapeutic approach for joint diseases. However, the use of IVT mRNA in human synovial cells has not been widely studied. Recently, the outbreak of the novel coronavirus disease has accelerated the development of innovative mRNA vaccines such as those containing a modified...

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Literature Corpus work: e3f609c8-71f6-54f5-8b58-df9e5e9445f4
DOI: 10.1101/2022.03.22.485393

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