Article
Engineering dynamic gates in binding pocket of penicillin G acylase to selectively degrade bacterial signaling molecules
2023-05-09
Abstract excerpt
The rapid rise of antibiotic-resistant bacteria necessitates the search for alternative, unconventional solutions, such as targeting bacterial communication. Signal disruption can be achieved by enzymatic degradation of signaling compounds, reducing the expression of genes responsible for virulence, biofilm formation, and drug resistance while evading common resistance mechanisms. Therefore, enzymes with such acti...
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Identifiers and source
- Literature Corpus work
- e3e1751a-bcfe-56f6-ad8e-917f64af5e1d
- DOI
- 10.1101/2023.05.09.538545