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Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1

26 Mar 2024

Abstract excerpt

Staphylococcus aureus, an ESKAPE pathogen, is a major clinical concern due to its pathogenicity and manifold antimicrobial resistance mechanisms. The commonly used β-lactam antibiotics target bacterial penicillin-binding proteins (PBPs) and inhibit crosslinking of peptidoglycan strands that comprise the bacterial cell wall mesh, initiating a cascade of effects leading to bacterial cell death. S. aureus PBP1 is...

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PMID: 38527711
DOI: 10.1016/j.jsb.2024.108086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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