Article
Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder.
Nature communications - 19 Jan 2026
Lee Che Yu, Hwang Ahyeon, McRiley Delaney, Lee Jaywon, Thibodeau Genevieve, Duman Catharine, Zhang Xiangyu, Skarica Mario, Coudriet Jensine, Xu Siwei, Terwilliger Rosemarie, Sliby Alexa-Nicole, Wang Jiawei, Nguyen Tuan, Liu Yujing, Li Hongyu, Dai Yi, Duan Ziheng, Lei Yutong, Lin Yingxin, Glausier Jill R, Lewis David A, Gelernter Joel, Holtzheimer Paul E, Xu Ke, Zhou Hang, Zhao Hongyu, Thompson Summer L, Krystal John H, Che Alicia, Taylor Jane R, Zhang Jing, Girgenti Matthew J
Abstract excerpt
Regulation of gene expression is a highly coordinated process in both the healthy and pathological brain with unique patterns across a multitude of cell types. Here we present a multi-omic single nucleus study of ~175,000 nuclei from 50 donors with alcohol use disorder (AUD) and control donors without AUD, profiling cell type specific gene expression and chromatin accessibility in the human central amygdala. We...
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