Single-cell multiomic human brain atlas reveals regulatory drivers of cortical regionality

Abstract excerpt

Distinct regional functionality of the human cortex is orchestrated by diverse cellular and molecular processes, yet the underlying regulatory mechanisms remain poorly understood. We performed multiomic single-cell and spatial characterization of nine regions of the human cortex to define the gene regulatory networks and transcription factors that govern cell-type and region specificity. With the combined data of...

Topics

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• Brain
• Cerebral Cortex
• Gene Expression Profiling
• Gene Regulatory Networks
• Genetic Predisposition to Disease
• Mental Disorders
• Single-Cell Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

7d48d8c6-7b3d-58ff-92ba-b8c060d63b40

DOI

10.1101/2025.08.07.667992