Back to search

Article

Individual differences in oxycodone addiction-like behaviors in a large cohort of heterogeneous stock (HS) rats

2022-07-28

Abstract excerpt

Family and twin studies demonstrate that genetic factors determine 20-60% of the vulnerability to opioid use disorder. However, the genes/alleles that mediate the risk of developing addiction-related behaviors, including the sensitivity to the analgesic efficacy of opioids, the development of tolerance, dependence, and escalation of oxycodone taking and seeking, have been ill-defined, thus hindering efforts to des...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e3a762c4-5668-5b5e-bba5-81f7150be6c9
DOI
10.1101/2022.07.26.501618
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Individual differences in oxycodone addiction-like behaviors in a large cohort of heterogeneous stock (HS) ratsDOI 10.1101/2022.07.26.501618
Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred ratsSemantic proximity
Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats.Semantic proximity
Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same constructSemantic proximity
A multi-symptomatic model of heroin use disorder in rats reveals distinct behavioral profiles and neuronal correlates of heroin vulnerability versus resiliencySemantic proximity
Sex differences and addiction severity influence methadone, buprenorphine, and naltrexone efficacy on oxycodone motivation in genetically diverse ratSemantic proximity
Addiction-Like Severity Predicts Prolonged Oxycodone Withdrawal-Induced Allodynia in Genetically Diverse RatsSemantic proximity
Genetic Architecture of Addiction-Relevant Behaviors in Outbred Sprague-Dawley Rats Reveals Loci for Anxiety-Like and Nociceptive Traits.Semantic proximity
Individual difference in addiction-like behaviors and choice between cocaine versus food in Heterogeneous Stock ratsSemantic proximity
Identification of individual differences in response to methadone, buprenorphine, and naltrexone in animal models of opioid use disorderSemantic proximity
Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred ratsSemantic proximity
Sex and heredity are determinants of drug intake in a novel model of rat oral oxycodone self-administration.Semantic proximity
Multiple elements of addiction vulnerability are independently heritable in ratsSemantic proximity
Select a neighboring publication to make it the new centre.