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Article

Sex and heredity are determinants of drug intake in a novel model of rat oral oxycodone self-administration.

Genes, brain, and behavior - 1 Nov 2021

Sharp Burt M, Fan Xinyu, Redei Eva E, Mulligan Megan K, Chen Hao

Abstract excerpt

The steady rise in prescription opioids such as oxycodone has led to a virulent epidemic of widespread abuse and deaths in the United States; approximately 80% of affected individuals initiate the habitual use of oxycodone by using prescription oral oxycodone. Given the importance of drug pharmacokinetics in determining abuse potential, we designed an oral operant oxycodone self-administration (SA) procedure in...

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Identifiers

PMID: 34459088
DOI: 10.1111/gbb.12770
PMCID: PMC8815756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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