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Article

Genetic variants associated with age-related episodic memory decline implicate distinct memory pathologies.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2025

Ali Amanat, Milman Sofiya, Weiss Erica F, Gao Tina, Napolioni Valerio, Barzilai Nir, Zhang Zhengdong D, Lin Jhih-Rong

Abstract excerpt

BACKGROUND: Approximately 40% of people aged ≥ 65 experience memory loss, particularly in episodic memory. Identifying the genetic basis of episodic memory decline is crucial for uncovering its underlying causes. METHODS: We investigated common and rare genetic variants associated with episodic memory decline in 742 (632 for rare variants) Ashkenazi Jewish individuals (mean age 75) from the LonGenity study....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39559945
DOI: 10.1002/alz.14379
PMCID: PMC11775541

Genes

CRHR2
ITSN1

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