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Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

15 May 2023

Abstract excerpt

Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 and DPB1*04:02) and discovered seven...

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PMID: 37188663
DOI: 10.1038/s41467-023-36120-z

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