Article
High-dimensional single-cell analysis reveals the immune signature of narcolepsy.
The Journal of experimental medicine - 14 Nov 2016
Hartmann Felix J, Bernard-Valnet Raphaël, Quériault Clémence, Mrdjen Dunja, Weber Lukas M, Galli Edoardo, Krieg Carsten, Robinson Mark D, Nguyen Xuan-Hung, Dauvilliers Yves, Liblau Roland S, Becher Burkhard
Abstract excerpt
Narcolepsy type 1 is a devastating neurological sleep disorder resulting from the destruction of orexin-producing neurons in the central nervous system (CNS). Despite its striking association with the HLA-DQB1*06:02 allele, the autoimmune etiology of narcolepsy has remained largely hypothetical. Here, we compared peripheral mononucleated cells from narcolepsy patients with HLA-DQB1*06:02-matched healthy controls...
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