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Article

The autoimmune basis of narcolepsy.

Current opinion in neurobiology - 1 Oct 2013

Mahlios Josh, De la Herrán-Arita Alberto K, Mignot Emmanuel

Abstract excerpt

Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness, cataplexy, hypnagonic hallucinations, sleep paralysis, and disturbed nocturnal sleep patterns. Narcolepsy is caused by the loss of hypocretin (orexin)-producing neurons in the lateral hypothalamus. Evidence, such as a strong association with HLA DQB1*06:02, strongly suggests an autoimmune basis targeting hypocretin neurons....

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Source

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Identifiers

PMID: 23725858
DOI: 10.1016/j.conb.2013.04.013
PMCID: PMC3848424

Genes

CTSH
DNMT1
TNFSF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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