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Article

Epigenome-wide association study of DNA methylation in narcolepsy: an integrated genetic and epigenetic approach.

Sleep - 1 Apr 2018

Shimada Mihoko, Miyagawa Taku, Toyoda Hiromi, Tokunaga Katsushi, Honda Makoto

Abstract excerpt

Narcolepsy with cataplexy, which is a hypersomnia characterized by excessive daytime sleepiness and cataplexy, is a multifactorial disease caused by both genetic and environmental factors. Several genetic factors including HLA-DQB1*06:02 have been identified; however, the disease etiology is still unclear. Epigenetic modifications, such as DNA methylation, have been suggested to play an important role in the...

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PMID: 29425374
DOI: 10.1093/sleep/zsy019

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CCR3

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