Article

Replication-associated solo-WCGW hypomethylation reflects cumulative immune activation across diseases

2025-04-29

Abstract excerpt

Global DNA hypomethylation is a hallmark of immune-mediated diseases, yet its regulatory significance remains unclear. Replication-associated loss of DNA methylation at solo-WCGW (W = A/T) CpGs has recently been proposed as a consequence of cell division. Here we systematically investigated genome-wide hypomethylation patterns across seven immune-mediated diseases. Most diseases exhibited global hypomethylation, p...

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Identifiers and source

Literature Corpus work: 125a9361-4be9-5921-95dd-bc75443706ef
DOI: 10.1101/2025.04.25.650620

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