Article
In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls.
Nature communications - 20 Nov 2019
Jiang Wei, Birtley James R, Hung Shu-Chen, Wang Weiqi, Chiou Shin-Heng, Macaubas Claudia, Kornum Birgitte, Tian Lu, Huang Huang, Adler Lital, Weaver Grant, Lu Liying, Ilstad-Minnihan Alexandra, Somasundaram Sriram, Ayyangar Sashi, Davis Mark M, Stern Lawrence J, Mellins Elizabeth D
Abstract excerpt
Individuals with narcolepsy suffer from abnormal sleep patterns due to loss of neurons that uniquely supply hypocretin (HCRT). Previous studies found associations of narcolepsy with the human leukocyte antigen (HLA)-DQ6 allele and T-cell receptor α (TRA) J24 gene segment and also suggested that in vitro-stimulated T cells can target HCRT. Here, we present evidence of in vivo expansion of DQ6-HCRT...
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