Article

Multiplex, quantitative, high-resolution imaging of protein:protein complexes via hybridization chain reaction

2023-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Signal amplification based on the mechanism of hybridization chain reaction (HCR) facilitates spatial exploration of gene regulatory networks by enabling multiplex, quantitative, high-resolution imaging of RNA and protein targets. Here, we extend these capabilities to the imaging of protein:protein complexes, using proximity-dependent cooperative probes to conditionally generate a single amplifi...

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Identifiers and source

Literature Corpus work: e370208f-2eba-593b-90f3-6210cd225129
DOI: 10.1101/2023.07.22.550181

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