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PASTA: Versatile Tyramine-oligonucleotide Amplification for Multi-modal Spatial Biology

2025-04-30

Abstract excerpt

Spatial proteomics techniques have revolutionized our understanding of tissue architecture, but are frequently limited by detection sensitivity, bioconjugation limitations, multiplexing capacity, and multi-modal integration. Here we present P rotein and nucleic A cid S erial T yramine A mplification (PASTA), a novel signal amplification approach that significantly enhances detection sensitivity while maintain...

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Literature Corpus work
03498540-0069-5f83-b431-ad43e3315291
DOI
10.1101/2025.04.30.651463
Open publication

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PASTA: Versatile Tyramine-oligonucleotide Amplification for Multi-modal Spatial BiologyDOI 10.1101/2025.04.30.651463
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