Article

TH301, a Circadian Clock Modulator, Emerges as a Novel Anti-oncogenic Agent for Human Pancreatic Cancer Cells: the Dispensable Roles of p53, CRY2 and BMAL1 in TH301-induced CDKN1A/p21CIP1/WAF1 Upregulation

2024-12-04

Abstract excerpt

<h4>Background: </h4> Pancreatic Ductal Adeno-Carcinoma (PDAC) is a highly aggressive cancer, with lim-ited treatment options. Disruption of the circadian clock, which regulates key cellular processes, has been implicated in PDAC initiation and progression. Hence, targeting circadian clock components may offer new therapeutic opportunities for the disease. This study investigates the cytopathic ef-fects of TH301,...

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Literature Corpus work: e353d0f4-6d07-51da-a5e1-c99d61889d0c
DOI: 10.20944/preprints202412.0409.v1

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TH301, a Circadian Clock Modulator, Emerges as a Novel Anti-oncogenic Agent for Human Pancreatic Cancer Cells: the Dispensable Roles of p53, CRY2 and BMAL1 in TH301-induced CDKN1A/p21CIP1/WAF1 UpregulationDOI 10.20944/preprints202412.0409.v1Read

TH301 Emerges as a Novel Anti-Oncogenic Agent for Human Pancreatic Cancer Cells: The Dispensable Roles of p53, CRY2 and BMAL1 in TH301-Induced CDKN1A/p21CIP1/WAF1 UpregulationSemantic proximity Read

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