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Article

Circadian transcriptome of pancreatic adenocarcinoma unravels chronotherapeutic targets

7 May 2024

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer characterized by a poor outcome and an increasing incidence. A significant majority (>80%) of newly diagnosed cases are deemed unresectable, leaving chemotherapy as the sole viable option, though with only moderate success. This necessitates the identification of improved therapeutic options for PDA. We hypothesized that there are temporal variations in...

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PMID: 38716727
DOI: 10.1172/jci.insight.177697

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