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Alpha-Heredin targets CAMKⅡ/DRP1-Mediated mitochondrial fission to trigger ferroptosis in pancreatic ductal adenocarcinoma

15 Jul 2025

Abstract excerpt

PURPOSE: This study investigates the anti-tumor mechanisms of the natural triterpenoid Alpha-Heredin in pancreatic ductal adenocarcinoma, focusing on its dual effects on mitochondrial dynamics (via CAMKⅡ/DRP1 signaling) and ferroptosis induction. METHODS: In vitro assays including CCK-8, EdU, colony formation, and flow cytometry were employed to assess Alpha-Heredin's effects on proliferation, migration, and cell...

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Cancer, Lipids, and Metabolism
Clusterin in disease pathology
Ferroptosis and cancer prognosis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40695089
DOI: 10.1016/j.phymed.2025.157048

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