Article

KRAS Inhibition Reverses Chemotherapy Resistance Promoted by Therapy-Induced Senescence-like in Pancreatic Ductal Adenocarcinoma

2025-04-18

Abstract excerpt

<h4>Background</h4> Emerging evidence suggests that chemotherapy can accumulate senescent-like cells within tumor tissues, a phenomenon linked to therapy resistance. The aim of this study is to analyze the senescence-like state of after-treatment persistent cells associated with KRAS mutational status to offer a therapeutic strategy to target these cells in pancreatic ductal adenocarcinoma (PDAC). <h4>Experimenta...

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Literature Corpus work: 901e83b6-f2e3-5d61-99c1-0f2549c530c6
DOI: 10.1101/2025.04.13.648164

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