Article

c-Myc inhibition and p21 modulation contribute to unsymmetrical bisacridines-induced apoptosis and senescence in pancreatic cancer cells

2024-04-12

Abstract excerpt

<title>Abstract</title> <p>Pancreatic cancer (PC) is one of the most aggressive cancers and is the seventh cause of cancer deaths worldwide. Mutations in the <italic>KRAS, CDKN2A, TP53, SMAD4/DPC4</italic>, and <italic>MYC </italic>are major genetic alterations associated with cell cycle deregulation, apoptosis inhibition, invasion, metastasis, and poor treatment outcomes in PC. The standard therapy for PC is gem...

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Identifiers and source

Literature Corpus work: 5017855d-fb42-548c-9fc3-c02db7123fa3
DOI: 10.21203/rs.3.rs-4176735/v1

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