Article

Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agent

2023-12-20

Abstract excerpt

<h4>ABSTRACT</h4> Increasing preclinical and clinical evidence has positioned high-dose vitamin C as a promising anti-cancer treatment that merits more clinical attention. Multiple cytotoxicity mechanisms have been described, including pro-oxidant effects. To contribute to the preclinical understanding of the broad pan-cancer effects of high-dose vitamin C in a global manner, we determined the IC50 of a large pan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52502666-46ee-537b-bf3b-da771c343e37
DOI: 10.1101/2023.12.19.572293

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agentDOI 10.1101/2023.12.19.572293Read

Proteomics, Personalized Medicine and CancerSemantic proximity Read

Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunitiesSemantic proximity Read

Advantages of Vitamin C Anticancer Therapy over Other Pharmacological InterventionsSemantic proximity Read

Role of bio‐flavonols and their derivatives in improving mitochondrial dysfunctions associated with pancreatic tumorigenesisSemantic proximity Read

High-resolution phenotypic profiling of natural products-induced effects on the single-cell level.Semantic proximity Read

Triphenylphosphonium-Conjugated Palmitic Acid for Mitochondrial Targeting of Pancreatic Cancer Cells: Proteomic and Molecular EvidenceSemantic proximity Read

Vertical RAS-pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterationsSemantic proximity Read

L-Ascorbic acid preferentially kills KRAS mutant pancreatic cancer cells through DNA damageSemantic proximity Read

Organoid Pharmacotyping of Pancreatic Cancer Enables Functional Precision Oncology and Drug RepurposingSemantic proximity Read

Role of Antioxidant Vitamins and Other Micronutrients on Regulations of Specific Genes and Signaling Pathways in the Prevention and Treatment of CancerSemantic proximity Read

TH301 Emerges as a Novel Anti-Oncogenic Agent for Human Pancreatic Cancer Cells: The Dispensable Roles of p53, CRY2 and BMAL1 in TH301-Induced CDKN1A/p21CIP1/WAF1 UpregulationSemantic proximity Read

Identifying simultaneous inhibition of riboflavin metabolism and MEK as a novel therapeutic strategy for pancreatic cancerSemantic proximity Read